Background: Atopic dermatitis (AD) is characterized by chronic inflammation of the skin. AD develops\nmainly in infants and young children. It induces skin disorders and signals the initiation of the allergic march\nincluding allergic asthma and rhinitis. Probiotics modify intestinal microbial populations in a beneficial way\nfor human and animal hosts by reducing inflammatory cytokines.\nObjective: As a result of their immunomodulatory properties, probiotics have been considered a promising\ntherapeutic option for the prevention and treatment of AD.\nDesign: In this study, we examined the effects of GI7, a potential probiotic mixture consisting of seven strains\nof bifidobacteria and lactic acid bacteria, on AD in a mouse model.\nResults: Administration of GI7 for 8 weeks reduced AD-like skin lesions and induced changes in the levels of\nserum markers such as immunoglobulin E and cytokines related to T helper (Th)1 and Th2 cells, and in skin\nbarrier genes. Alleviation of AD seems to be associated with GI7-induced generation of CD4Foxp3\nregulatory T cells.\nConclusions: The probiotic mixture may have potential to improve symptoms of AD.
Loading....